Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.
The usual adult dosage for Vicodin 5 mg/300 mg is 1 or 2 tablets. This is taken every 4-6 hours as needed for pain. Also, the total daily dosage should not exceed 8 tablets.